Evaluation of the acid-neutralizing and cytotoxicity properties of novel plant mucilage used as an alternative treatment for peptic ulcers and as antacids in Namibia

Hypersecretion of gastric acid damages the stomach lining, causing formation peptic ulcers. Mucilage from medicinal plants offers a relaxing and soothing effect to endodermal lining gut has antacid properties, which can protect mucosal acidity. This is first report aimed evaluate physicochemical characteristics, acid-neutralizing, cytotoxicity properties traditionally used aqueous mucilage Asparagus exuvialis Sesamum capense. The were determined by biochemical methods. Acid neutralizing buffering capacities titration Normal mouse embryonic fibroblast cells for evaluation MTT assay. characterization confirmed presence carbohydrates, alkaloids, saponins, proteins, tannins, flavonoids, glycosides. capense exhibited most potent artificial juice capacity pH 4.62±0.01, 8.0±0.00 neutralization per gram acid, 30 minutes duration neutralization. S. did not cause any significant 3T3 cell lines showing an IC50 value 91.5 ± 0.06 μg mL-1, confirming safe nature mucilage. These findings revealed that potential neutralize responsible ulceration be safely consumed.